Recently, based on recommendations from Jen and myself, another web designer of note moved her hosting to Liquidweb. I'm sorry to say she had an agonizing period of adjustment. It was all about the dreaded file permissions and ownership.
In Mambo and J10, it was often necessary to set certain files and directories to be writable by anyone. Due to the way web servers have traditionally been set up, the only way a system like Joomla could upload files and modify the website's directory structure (when installing an extension for example) was by making the file system, even if only temporarily, writable by the whole world.
We were pleased to see the addition of the ftp layer in Joomla 1.5. It meant not having to open up the file system like this. But even in J15, certain 3rd party extensions require a directory here and there to be set world writable. It has recently come to my attention that some webhosts will shut down your account if any files or directories are set this way.